The PC version of Ninja Gaiden: Master Collection would have several problems: according to what reported by Kotaku, it would be one of the laziest and most inconsistent conversions ever.
Despite being capable of shooting at 4K and 60 fps on PC, Ninja Gaiden: Master Collection features very few options, and even lacking basic adjustments such as the ability to activate the full screen or use the keyboard.
There are only three resolutions available (720p, 1080p and 2160p) but they must be set from the game properties on Steam rather than in-game, while the possibilities regarding the management of the view are limited to the inversion.
As mentioned, mouse e keyboard are not supported by the game, which necessarily requires a controller to be used, even simply to navigate the menus.
In short, it seems that the developers who have taken care of the conversion of Ninja Gaiden: Master Collection for PC have really limited themselves to the bare minimum, without however considering the now rather high standards of many other productions.