Geloni out of season and not related to the use of drugs. The strange symptom it had already been detected during the first wave of Covid in children and adolescents. Many of them have seen the same symptoms reappear, after a year, without being positive. Scientists have different explanations for this a posteriori manifestation of the infection.
Covid chilblains: perhaps caused directly by the coronavirus
Two Spanish study groups, Corriere della Sera reports, have found traces of Sars-Cov-2 in the blood vessels and sweat glands of seven patients with chilblains, which however tested negative for both the molecular swab and the serological test.
Scientists would have identified the proteina Spike characteristic of the coronavirus at the level of the endothelium, the tissue that lines the blood vessels. Even finding with a microscopic analysis on a frost of the circular shapes attributable to Sars-Cov-2.
These findings would confirm that Covid-19 is not only a respiratory disease, but also attacks the circulatory system, causing vascular alterations such as chilblains, when the virus enters the circulation.
Internationally the chilblains are up to 20% of the demonstrations cutaneous linked to the pathogen, particularly among children and adolescents.
Another hypothesis is that chilblains are linked to the coronavirus due to the role of the receptor Ace2, used by Sars-Cov-2 to invade cells, and which has been identified in the nerve glands of the hands and feet and in blood vessels.
Covid chilblains: possibly caused by an immune response
Other working groups, one German and one French, have instead highlighted a connection with theinterferon, a protein that regulates the early immune response to the coronavirus.
Inside the chilblains, scientists have detected high levels of interferon, which could be one indicator light of the different way in which the body of the youngest reacts to Covid infection.
“It is possible that the coronavirus is able to induce one in some young patients overabundant response of interferon ”, said Sebastiano Recalcati, dermatologist at the Lecco hospital, one of the first to have studied the phenomenon.
This also happens to “patients who suffer from interferonopatie, genetic diseases that determine an overproduction of interferon and which also result in the development of chilblains “.
Covid chilblains: why having them could be a good sign
These findings could represent one good news, according to what Sebastiano Recalcati reported to Corriere della Sera. “When a child comes into contact with the virus through the respiratory tract, the immune response of the child is immediately activated innate system, which anticipates the antibody “.
“A high level of interferon is therefore produced, usually created in large quantities in childhood. Interferon goes to inhibit viral replication, which is why the swabs are negative, ”he explained.
“Likewise the protein inhibits the adaptive response“, Or the one“ that makes antibodies produce, and this is perhaps one of the reasons why the serological tests result negative“.
The result is that “they are not produced neutralizing antibodies, and this could be the cause of the relapses. With new contact with the virus, patients develop chilblains again ”instead of the other symptoms.
Considering also the cases reported after the administration of Pfizer and Moderna mRna vaccines, “perhaps chilblains are not a damage direct of the virus, but are caused by the Spike protein, which generates high interferon responses, which together with other mechanisms in turn cause chilblains ”.
“Trivially” the chilblains “could turn out to be an indicator of a ‘efficient immune response against coronavirus. Those who suffer from chilblains have one prognosis Great and does not develop the respiratory disease. A little temporary side effect it may mean that the virus has been eradicated in a natural way “.
Virgil News | 06-15-2021 12:24
Photo source: ANSA