Rome – According to the plan of General Francesco Figliuolo at the end of September 80% of the population will be vaccinated. By that date, the government reassured, the health emergency due to the pandemic will be overcome. Vaccination hubs will disappear and more and more pharmacists and GPs will be involved. Also in view of the need for a third dose. Will it really be necessary? And if so, at what time distance from the second dose recall? And then: what coverage do we have between the first and second dose of the vaccine? If I have Covid I am covered, but until when? Another question: is it necessary to do the serological before the vaccine or immediately after to understand what is the level of antibodies?
✉ COVID IN LIGURIA: SUBSCRIBE TO THE NEW NEWSLETTER
As we see, the questions are many. A year and a half after the start of the pandemic, however, we know more than just a few months ago. So let’s try to line them up, one by one.
Undersecretary for Health Andrea Costa assures that “the third dose of vaccine will be absolutely foreseen”. And he adds: “Studies tell us that approximately the year will be the time frame in which this recall must be made.” And by then “we will no longer be in an emergency situation: we will have an organized structure on the territory, there will obviously be the possibility of a different planning and organization”. The reference is to what Figliuolo affirms, with the elimination of vaccination hubs and an organizational strengthening of territorial medicine.
But how much is the third dose really needed?
If on the one hand the need to reach a third dose seems to be a path outlined, on the other hand it is not yet clear whether it will be possible to use, for example, a different vaccine than the one used for the first dose and for the booster. Think, for example, of all those who have received the double dose of AstraZeneca: will they be able to have the third booster with another vaccine? For example Pfizer? And we still don’t know for sure how much this third dose will be needed.
On the issue there is a study that is being carried out in the United Kingdom: nearly 3,000 volunteers will receive a third dose of the vaccine as part of a trial to investigate which vaccines to use as “booster” doses. The reason is simple: to understand which vaccines are most effective to combat the variants, avoiding new waves but also to check for any adverse reactions.
Posted by Cov-Boost studio is the first in the world to investigate the need for the third dose in patients who have already received the double dose of Pfizer and AstraZeneca vaccine. The nearly 3,000 patients will be monitored for a year, with blood drawn at regular intervals.
Professor Giovanni Di Perri, virologist and head of the Department of Infectious Diseases of the Amedeo di Savoia also intervenes on the question: «To date there are no precise data that show us the correct path. It may be that a third dose will be needed to deal with variants, such as the Indian one which is proving particularly aggressive. Or it will also be likely that the various pharmaceutical companies that have launched messenger MrNA vaccines will prepare a unique product capable of counteracting the variants themselves ». In short, we will have to wait.
For now who received the first and second dose, how much is covered?
According to the official Aifa document, “the duration of protection is not yet defined with certainty because until now the observation period has necessarily been a few months, but the knowledge on other types of coronaviruses suggests that it should be at least 9-12 months “.
Can vaccinated people still pass the infection to other people?
The answer is yes. But the odds are very low. Also in this case the Aifa document comes to our aid. “Since it is possible that, despite protective immunity, in some cases the virus may persist hidden in the nasal mucosa, vaccinated people and those who are in contact with them must continue to take protective measures against COVID-19.”
Can anyone who has already had a COVID-19 infection confirmed by molecular testing be vaccinated? Do I need to have a serological test before the vaccine and after administration?
Another much debated issue. The Aifa also replies as follows: “People who have had a SARS-CoV-2 infection confirmed by molecular (or third generation antigenic) test, both with symptoms and without symptoms, will receive a single dose of vaccine administered after at least 3 months, but no later than 6 months after infection. On the contrary, they will receive the two doses, if they are immunocompromised or on immunosuppressive therapy. The uselessness of serological or molecular tests before and after vaccination is underlined ».
Another point: Do people who become infected with SARS-CoV-2 after receiving the first dose of the vaccine need to receive the second dose?
Much has already been said on this aspect. There are numerous studies that show how getting sick and recovering from Covid 19 guarantees strong immunity, equal to or even greater than the vaccine. If after receiving the first dose you fall ill (the risk, albeit mild, exists) Aifa recommends this: «the infection itself represents a powerful stimulus for the immune system that is added to that provided by the first dose of vaccine. In light of this and the fact that natural infection confers a specific immune response to the virus, it is not appropriate to give these people the second vaccine dose. Partial vaccination and subsequent infection do not preclude a possible recall of COVID-19 vaccination in the future, if the data on the duration of immune protection indicate this need “.