Covid, first and second dose vaccine mix authorized in Canada. Popoli (Aifa): “Interesting hypotheses but there are few data”

While in Italy it is thought of the hypothesis of mixing two different anti Covid vaccines between the first and second dose in Canada the procedure was authorized by the health authorities. Those who have received a first dose of the compound developed by the Oxford researchers and marketed by AstraZeneca, can turn to Pfizer or Moderna for the second. Similarly, the two immunizations based on messenger RNA technology – viz Pfizer e Modern – they can be alternated between first and second dose. However, the Canadian authorities also point out that it would be optimal to use the same vaccine for both doses. The mix is ​​already licensed in Finland and there are studies in many countries to test the possibility. D.

and searches have already been disclosed: one in the UK and the other in Spain. In the first case – tests on 830 people – it emerges that the use of a mix of anti Covid vaccines (AstraZeneca and Pfizer) – tested in Great Britain – appears capable of producing a slightly higher frequency of non-serious side effects “in the short term “, But it does not involve” safety concerns “for people. o study – on the use of the messenger RNA vaccine and the viral vector vaccine – did not verify substantial differences between the administration of a first AstraZeneca dose and a Pfizer booster and the reverse. The clinical study – 673 volunteers – by theCarlos III Health Institute, a Spanish public body, has concluded that giving Pfizer’s anti-covid vaccine as a second dose to people who have received the first of AstraZeneca is safe and increases the immune response.

“Having the ability to mix Covid vaccines between first and second doses is an interesting option and there is a hypothesis of an encouraging effect,” but there are still no definitive and published scientific data on the matter“The president of the Technical Scientific Commission of the Italian Medicines Agency (Aifa) underlines to Ansa, Patrizia Popoli, noting that “until the studies are published we cannot say anything more and both the efficacy and safety profiles will have to be evaluated well. Having the possibility of mixing vaccines – explained Popoli – is an interesting hypothesis because it would also support the flexibility of the vaccination campaign and would still allow full vaccination to be continued in subjects who have already received the first dose of AstraZeneca but in whom it may be more appropriate to use another vaccine. In theory, therefore, it is undoubtedly an interesting hypothesis ”. However, the expert points out, “the data available to date are limited. A Spanish study has been concluded and it is known that the data obtained would be positive even if they have not yet been published, and then there is an English study of which only some preliminary and descriptive data have been published while more substantial data with an analysis statistics are expected by June “. And today the English study was published on The Lancet.

Therefore, he notes, “we still have no published studies and the English data are absolutely initial: they indicate a greater onset of mild side effects with the use of the mix of vaccines. These major side effects could be associated with an increased immune response, but this has yet to be demonstrated. In short, “until the studies are published we cannot say anything more, and both the efficacy and safety profile must be well evaluated. On paper, however, if it were confirmed as effective and safe – concludes the president of the Aifa Technical Scientific Commission – the vaccine mix could be a very interesting option ”.

His Lancet studied it

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