(ANSA) – TRIESTE, 26 JUL – SARS-CoV-2 can lead to heart problems and it is estimated that over 40% of hospitalized patients have indicators of heart damage. It is not the virus itself that causes them but a key role in heart damage during coronavirus infection is previous comorbidities (pre-existing heart disease), the severity of pneumonia and impaired oxygenation, and systemic inflammation. To support it – explains prof. Gianfranco Sinagra, director of the School of Specialization in Cardiovascular Diseases of the University of Trieste and of Cardiology – is a study based on the experience of cardiovascular pathology of Professor Rossana Bussani of the Institute of Pathological Anatomy of Asugi-University of Trieste , critically analyzed with fellow cardiologists from the Cattinara hospital (Trieste) and molecular researchers from Icgeb, the Trieste International Center for Genetic Engineering and Biotechnology.
If in previous pandemics myocarditis was described with a frequency of up to 20-30% of autopsy cases, this work argues – explains Sinagra – that, on the other hand, “myocarditis was identified in less than 2.5% of cases, and, that myocarditis does not seem to be caused directly by the coronavirus as the molecular search for the viral genome was negative. The heart in the analyzed cases, even if spared from inflammatory damage (myocarditis), showed non-specific forms of damage in relation to the severity of hypoxia and pre-existing heart disease “. In fact, the study – summarized in an article clinically coordinated by Matteo Dal Ferro, cardiologist and researcher, published in the journal Clinical Research in Cardiology – analyzed the impact of SARS-CoV-2 infection on the myocardium, in a series of autopsy cases from Trieste who died of severe Covid19 pneumonia during the first epidemic wave. Based on a pathological and molecular analysis, the study showed that although the virus spreads ubiquitously in particular in the lungs, at the time of death it is practically impossible to find in the heart. The histological analysis performed represents one of the most accurate and detailed in the literature, completed by the most modern molecular research techniques of the viral genome.
The implications of these discoveries, which extend experiences already published, also extend to other areas: in outpatient cardiology they will help to monitor the disease more closely in known heart patients and in sports medicine, for example, they can contribute to correct management. of athletes returning from coronavirus infection carrying any outcomes. (HANDLE).
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