Genoa – “It is very important to tell everything to the doctor who takes the medical history before vaccination: it is better to say something useless, rather than omitting important information about your state of health or about the drugs you are taking”. The recommendation is Emanuele Pontali, director of the complex structure of infectious diseases at the Galliera hospital in Genoa, the city where the case of a girl suffering from thrombosis was reported yesterday, about ten days after being vaccinated with AstraZeneca.
“We must continue to monitor with the utmost attention all the effects of vaccines against Covid19, but – underlines Pontali – from the data we have to date there are no indications that lead to a change of strategy in the vaccination campaign”. The specialist recalls, in fact, that for the AstraZeneca vaccine “there have been no recommendations against, but only a recommendation to be careful when it comes to women and people under the age of 50. But zero risk does not exist, just as it does not exist for drugs, and here we are talking about one case in a million”.
However, even those who get vaccinated should not underestimate the conversation with the doctor that precedes the administration of the vaccine. “For each person, the doctor evaluates the risks and benefits of vaccination and, in fact – explains Pontali – it happens that, after the anamnesis, some are given a different vaccine than the one expected. Precisely for this reason it is very important to tell the doctor everything, knowing that that information will obviously remain confidential. For example, there are people who – says the doctor – take drugs but do not consider them as such and, therefore, may think they do not even have to talk about them. But is not so”.
The differences between the vaccines currently used against Covid-19 are linked, as is known, to the different vector that carries the sequence of the genetic code (rna) in the cells, which triggers the production of the spike protein, and therefore the response of our immune system. With Pfizer and Modern “RNA produced in the laboratory is inoculated into the cells mixed with fat-based substances” explains Pontali. The systems that produce the proteins read the RNA and “produce the spike protein. The cells of the immune system recognize it and start producing antibodies ”. With the AstraZeneca and Johnson & Johnson vaccines, on the other hand, “RNA is introduced into the cells through a modified virus”, after which a similar sequence of reactions is determined. “Unfortunately we – observes Pontali – we are used to making comparisons with long-time proven drugs and vaccines, while now we have found ourselves with new vaccines and a mass campaign of adults. It is therefore important to continue to monitor all reactions and to collect as much information as possible, as is being done, because in Italy and in Europe there is an important and rigorous pharmacovigilance system ”. –