Third dose of vaccine, what are the side effects? –

Third dose of vaccine, what are the side effects? –
Third dose of vaccine, what are the side effects? –
from Laura Cuppini

According to data released by the Israeli Ministry of Health, adverse events related to vaccination are less frequent in those who receive the booster

the hypothesis of offer the entire adult population the third dose of the Covid vaccine. For now in Italy the recall, with mRna vaccines, is reserved, in order of priority, for immunocompromised people, over 80, residents of the Rsa, health personnel, over 60 and frail. Received the booster also Ilaria Capua, director of the UF One Health Center of the University of Florida, who guest at Of Tuesday he said: To the people who will now get vaccinated, know that it feels. I tell you in such a way that afterwards who knows what stories do not come out.

Israeli data

Therefore, even after the third dose, mild complaints are possible. In fact, according to data released on October 1 by the Israeli Ministry of Health, the effects of the recall are significantly lighter than those of the first two injections. The most common result general exhaustionfound in 86.6 people per million versus 271.8 and 251.1 per million after the second and first dose, respectively. Pain in the vaccination area it affected 42.7 people per million in the third dose, against 222.9 and 514.3 in the second and first. The data refers to approx 3 million 200 thousand immunizations with the booster (today there have been 3 million and 900 thousand): there were 19 serious disorders but the possible connection with the vaccine is still being evaluated. The Faq published on the Israeli Ministry of Health website reads: Side effects after the third dose have been found in a small percentage of adults aged 60 and over and are consistent with those observed after the first two doses or other vaccines; generally include pain in the injection area, headache, fever, chills, muscle pain.

Within 48 hours of vaccination

The American Centers for Disease Control and Prevention (CDC) also examined the side effects of the third dose of the vaccine, concluding – in a report published on September 28 – that they are similar to those observed after the other doses. CDC experts say that adverse events are mostly moderate or mild and do not last long. As with the first doses, symptoms appeared within 48 hours of vaccination. The analysis was done on over 2,200,000 Americans who had received the third dose as of September 19. About 22 thousand responded voluntarily to a questionnaire: 28% had problems the day after vaccination. The most frequent symptom was arm pain, warned in 71% of cases. 56% reported tiredness, 43.4% headache. 7% had severe pain. 2% made use of medical assistance, 13 people were hospitalized. The percentages are in line with those relating to the second dose of vaccine. There are still no data on the risk of myocarditis and pericarditis after the third dose, also because at the moment the booster was offered only to the higher age groups (in the USA over 65 and frail subjects), while post-vaccine heart problems (very rare and not serious) mainly affected young people.

Third dose and booster

According to several studies, the effectiveness of vaccines begins to decline between 6 and 9 months after the last injection. But for immunosuppressed individuals, protection fails much sooner. That is why a distinction was made between third dose and booster: the third dose can be done 28 days after the second and aims to complete the vaccination course in people who have not responded effectively to the first two injections. The recall, on the other hand, can be done starting from 6 months after the second dose and aims to reactivate the production of antibodies.

95 percent effectiveness

In fact, according to a study published in recent days on the New England Journal of Medicine, the efficacy of the third Pfizer dose was 95.6%, with 5 cases of infection in the vaccinated group, versus 109 infections in the placebo group (2 Pfizer doses, plus the third with placebo). The results of the trial were presented to the Advisory Committee of the American Food and Drug Administration (FDA): neutralizing antibodies were found to be high against all variants, including Beta and Delta. In addition, the maximum effectiveness of the third dose is reached after 7 days. One fifth of the study participants were over the age of 65, a category most at risk of severe Covid. The effectiveness numbers are about the contagion: the ability of vaccines to combat deaths and hospitalizations exceeds 90 percent (and close to 100%) in any analysis even with only the two doses of vaccine, but protection against infections weakens after 6 months, especially in the most exposed categories, for which the third dose is useful.

For Moderna, half a dose is enough

Recently the European Medicines Agency (Ema) gave the green light to the administration of the third dose of Modern vaccine (Spikevax) in people aged 18 and over. For the booster (to be done 6-8 months after the second dose) a half dose is sufficient. The available data, says the EMA, indicate that the risks of side effects after the third dose are similar to those seen after the second. Previously, the Agency had already given the green light for the administration of the third dose of the vaccine Pfizer-BioNTech (Comirnaty) 18 years and older, six months after the second dose. In addition, the EMA stressed that a third dose of both vaccines can be administered to people with severe immune system deficiencies starting 28 days after the second.

October 27, 2021 (change October 27, 2021 | 18:42)


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