Covid vaccines: 5360 deaths and 240,000 adverse events in the EU

By Filippo Della Santa,

L’EudraVigilance, the European database for the management and analysis of reports of suspected adverse events to authorized medicines, updated the report on adverse reactions detected in Europe following the anti-Covid-19 vaccination campaign as of March 27, 2021.
So let’s see what are the most recent data available to us for drugs currently authorized by the European Medicines Agency (EMA), at three months since the beginning of vaccinations.

Covid AstraZeneca vaccine

Relating to the AstraZeneca anti-Covid vaccine ChAdOx1 nCoV-19 have been reported 107.733 adverse events, of which 82,645 in the age group between 18 and 64 years:

The states with the most adverse events reported are the Netherlands (10,324 cases), Italy (7,264 cases) and France (7,214 cases):

Cases by country_AstraZeneca
Of all reactions, approximately 62% are referred to as “severe“And, as indicated by the EMA, they correspond to a:

“Medical event that causes death, is life-threatening, requires hospitalization, causes other illness of medical importance or extension of existing hospitalization, causes persistent or significant disability or invalidity, or represents a congenital anomaly or defect in the birth. In addition, it can refer to other important medical events that may not be immediately related to a life-threatening or result in death or hospitalization, but could compromise the patient or require intervention (treatment) to avoid any of the other outcomes listed above. “

Relative to the fatal outcomes are counted 837 deaths following the administration of the Covid AstraZeneca vaccine, as we can see in the figure:

Deaths by type of adverse reaction_AstraZenecaVaccino Covid Pfizer/Biontech

Regarding the Pfizer / Biontech anti Covid vaccine Tozinameran have been reported 121.514 adverse events, of which 96,577 in the age group between 18 and 64 years:

Individual cases_PfizerItaly is in first place for the number of individual cases reported (36,295 cases), followed by France (12,124 cases) and the Netherlands (12,046 cases):

Cases by country_PfizerOf all reactions indicated by Eudravigilance, approximately 31% are indicated as “severe”.
It is also possible to extract a total of 3268 deaths following the administration of the anti Covid Pfizer / Biontech vaccine, as we can see in the figure:

Deaths by type of adverse reaction_PfizerCovid Moderna vaccine

Relating to the anti Covid Moderna vaccine CX-024414 as of March 27 they are detected 9625 adverse events (approximately 47% of which indicated as “serious”), of which 6059 in the age group between 18 and 64 years:

Individual cases_ModernItaly is in third place with 922 cases, behind the Netherlands (1956 cases) and Spain (937 cases):

Cases by country_ModernRegarding the 1255 deaths finally, the situation for the different categories of reactions available on the EMA platform is summarized in the figure:

Deaths by type of adverse reaction_ModernConclusions

From these data some anomalies emerge immediately to be reported, such as the high number of adverse events relating to our country.
This could be justified if Italy were ahead in the vaccination campaign, but there are no substantial differences compared to other European countries in terms of doses administered per 100 people, as we can see in the figure:

Doses administered for 100 people
Doses administered per 100 people, source

Another anomaly that emerges for Italy is the low reporting rate for adverse reactions following the AstraZeneca vaccine. In fact, we recall that for AIFA:

“The Decree of the Ministry of Health of 30 April 2015 reiterated the obligation to promptly report suspected adverse drug and vaccine reactions and defined the time limits within which healthcare professionals are required to report to the AIFA National Pharmacovigilance Network (RNF). “

It remains difficult, therefore, to believe that as of March 27 there are only 7200 suspected adverse events reported, and the simplest explanation of these inconsistencies is provided by the European Medicines Agency itself:

“The data available on the portal is based on adverse reactions reported spontaneously from patients, healthcare professionals or other sources, which are subsequently sent electronically to EudraVigilance in the form of an ICSR by the national medicines regulatory authorities or pharmaceutical companies. “

Such a surveillance system passive, therefore without an automatic recording of the event, it risks leading to a strong underestimation of adverse reactions, and this would explain the anomalies observed above.
This is also the case for the US database Vaccine Adverse Event Reporting System (VAERS), for which this 2011 Harvard Pilgrim Health Care report suggests how less than 1% of all vaccination-related adverse events are reported to the US government.

With regard to the incidence of individual drugs, the doses administered for each type of product are not available for all EU countries, however the portal provides this classification for some states, including Italy, from which we have deduced the reporting rate of adverse reactions for 100,000 doses, summarized in the figure:

Incidence rateIf we also consider the data coming from Great Britain, we conclude that there are no substantial differences in terms of danger between the vaccine that has fallen into the spotlight, the ChAdOx1 nCoV-19, and those of Pfizer and Moderna.
So why are we talking about AstraZeneca’s problems but not about those related to experimental mRNA vaccines?
The answer is not simple. It could simply be a media issue given the age groups involved, or there could be a relationship with issues of an economic and / or geopolitical nature.
What is certain, however, is the lack of transparency on the part of our politicians and health officials, of which we report only one of the many examples.

Interviewed by tg2 (minute 14:45), the director of the San Martino Polyclinic in Genoa Salvatore Giuffrida comments on the death of the young Ligurian teacher on Sunday 4 April, following a thrombotic picture and cerebral hemorrhage:

“In Italy for a similar disease every year 600,000 cases occur with 200,000 deaths, so I would say completely impossible to put it in close relationship with the vaccine”

What the director forgot to add, certainly in good faith, is that for the 200,000 deaths from diseases of the circulatory system (which include also thrombosis) recorded in 2018 by ISTAT, only 8000 occurred in the age group affected by recent news events:

Mortality by territory of event

While the turnarounds on AstraZeneca continue throughout Europe, as well as the stubborn silence on Pfizer and Moderna, media and politicians are scrambling to deny the correlations and dangers of these drugs still in the trial phase.
What remains three months after the start of vaccinations, in spite of consent free e informed, are the 240,000 adverse reactions reported and the 5360 people died.

By Filippo Della Santa,

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