AstraZeneca vaccine and thrombosis: Aifa announcement on the second dose

We go back to talking about the Covid vaccine AstraZeneca and the rare cases of thrombosis associated with it. Aifa, the Italian Medicines Agency, has announced that the second dose of the AstraZeneca vaccine should not be administered in case of thrombosis after the first dose. The clarification also contains a detailed reference to the symptoms which must be carefully evaluated.

AstraZeneca vaccine, new recommendations from Aifa

Currently the AstraZeneca vaccine it is recommended in Italy for the over 60s and is “contraindicated in subjects who have presented thrombotic thrombocytopenic syndrome (TTS) following the previous vaccination with Vaxzevria”, specified the Italian drug agency Aifa in an official note, providing “updates on points that emerged from the assessment of the risk of thrombosis in combination with thrombocytopenia ”.

“Subjects diagnosed with thrombocytopenia arising within 3 weeks of vaccination with Vaxzevria – added Aifa – must be actively evaluated for signs of thrombosis. Likewise, the subjects who submit thrombosis within 3 weeks from vaccination should be evaluated for thrombocytopenia “.

AstraZeneca and thrombosis, the current situation

“A combination of thrombosis and thrombocytopenia, in some cases accompanied by bleeding, has been observed very rarely after vaccination with Vaxzevria ”, underlined Aifa in an information note addressed to doctors and health professionals, agreed with the European regulatory authorities.

“This manifestation includes severe cases that present themselves as venous thrombosis, also in unusual sites of onset, such as cerebral thrombosis of the venous sinuses and splanchnic venous thrombosis, as well as arterial thrombosis in conjunction with thrombocytopenia. Some cases have had a fatal outcome. Most of these cases occurred in the first 3 weeks following vaccination and occurred mainly in the women under the age of 60“.

Thrombosis, the symptoms to keep under control

Finally, the AIFA also indicated which are the symptoms to watch for: “Healthcare professionals should pay attention to the signs and symptoms of thromboembolism and / or thrombocytopenia. Vaccinated individuals should be instructed to seek immediate medical attention if they develop symptoms such as shortness of breath, chest pain, leg swelling, leg pain, persistent abdominal pain after vaccination“.

“In addition – the body added in the note – anyone who exhibits neurological symptoms including severe or persistent headache, blurred vision, confusion or convulsions after vaccination or bruising (petechia) in a site other than that of vaccination after a few days, you must immediately consult a doctor ”.

“Healthcare professionals must report any suspected adverse reactions associated with the use of Vaxzevria in accordance with the national spontaneous reporting system”, concluded Aifa, highlighting “the importance of reporting the name of the vaccine product and the details of the batch” .



Virgil News | 03-06-2021 13:26



Covid vaccines and thrombosis, here are the symptoms to watch out for

Photo source: ANSA

Covid vaccines and thrombosis, here are the symptoms to watch out for

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