Another possible explanation of the rare cases of thrombosis attributable to the Astra Zeneca vaccine – Corriere.it

Another possible explanation of the rare cases of thrombosis attributable to the Astra Zeneca vaccine – Corriere.it
Another possible explanation of the rare cases of thrombosis attributable to the Astra Zeneca vaccine – Corriere.it
from Daniela Natali

A new hypothesis is added to the explanation of the mechanisms underlying the risk of thrombosis following vaccination with a viral vector

Another possible explanation has been found for the rare cases of thrombosis recorded after the inoculation of the AstraZeneca anti-Covid vaccine. A group of Cardiff scientists , in an Alpine research published in Science Advances, explained how a blood protein is “attracted” to a certain component of the serum and this attraction constitutes the “trigger” of a chain reaction that can cause the formation of dangerous coagulthe. Responsible would be the viral vector used in the AstraZeneca anti-Covid vaccine that attracts the “platelet factor four protein”, a protein that binds heparin in the body, an anticoagulant that contributes to the delicate balance between blood clotting and anticoagulation mechanisms .

New gusset

This is a new piece that adds to the previous explanations of the rare, very rare cases of thrombosis that occurred after vaccination with Astrazeneca but – underlines Fabrizio Pregliasco, virologist, professor of General Hygiene and Preventive Medicine at the University of Milan- the risks are far lower than those that can lead to the development of the disease. And the decision to designate this type of vaccine only for people over the age of 60 (given that the majority of thrombotic patients were women between the ages of 20 and 50) added an additional safety margin. And now, for the third doses, the AstraZeneca vaccine will no longer be useful even for those who had done the first two with this product.
I would like to add that the negative focus on vaccines, and in particular on AstraZeneca, did not affect the trust in these products which all have an excellent risk-benefit ratio. and constitute a fundamental tool in the fight against the virus. The narrative must be turned upside down and focused on the value and effectiveness of vaccines ”

Another hypothesis

On the vaccine-induced mechanism leading to thrombosis with thrombocytopenia (platelet collapse), in June, a group of geneticists from the universities of Frankfurt and Ulm had already presented data from a research, conducted by Rolf Marschalek, in which what had been defined was explained Vaccine-induced Covid-19 mimicry syndrome. COVID-19 vaccines that use adenovirus vectors, such as AstraZeneca (but also Jansen & Jansen) send instructions for making coronavirus proteins to the cell nucleus. Here, it occurs due to the very rare risk that they develop mutant versions of the Spike protein (the “key” that allows the virus to enter cells) which can help trigger blood clots in about 1 in 100,000 people.

The pioneers

These studies were preceded by another research, carried out in April 2021, conducted by Andreas Greinacher, of the University GKing
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Forest. Researchers from this German University were the first to report the rare and severe thrombosis and thrombocytopenia induced by the AstraZeneca vaccine. Months later, scientists from the Department of Transfusion Medicine have published their conclusions on the New England Journal of Medicine.The vaccine in very rare cases can trigger a mechanism very similar to that of a hepar-induced thrombocytopenia.in

a; the clinical picture occurs approximately 1-2 weeks after vaccination. In heparin-induced thrombocytopenia the drug combines with a protein produced by platelets, called platelet factor 4 (PF4), forming a complex. In some patients, the immune system recognizes this heparin-PF4 complex as foreign and, as a result, produces an antibody directed against it (anti-heparin / PF4 antibody). The binding of the anti-heparin / PF4 antibody to the heparin-PF4 complex activates the platelets, leading to their aggregation and decrease in their number (thrombocytopenia)), But the dangerous anti-PF4 antibodies, which induce cerebral vein thrombosis and other unusual thromboses after vaccination, disappear in most patients within three months. According to Professor Andreas Greinacher, patients can therefore be vaccinated a second time without fear of a recurrence.

Possible impurities

Another explanation of the risks associated with Astrazeneca vaccines calls in causes vaccine impurities, according to research conducted by Stefan Kochanek of the University of Ulm.According to the study, from May 2021, batches of the vaccine contained greater proportions of human and viral proteins than might be expected, proteins probably originating from the cultures of the vector viruses and conceivable, according to the researchers, that this contamination could affect the effect of the vaccine and also promote side effects such as sinus vein thrombosis.

December 2, 2021 (change December 2, 2021 | 19:24)

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