Covid, duration of immunity and third dose. 12 million already have fewer defenses

Covid, duration of immunity and third dose. 12 million already have fewer defenses
Covid, duration of immunity and third dose. 12 million already have fewer defenses

Twelve million people would already need the third dose. This is the number of Italians who immunized between January and May and who, according to the latest studies published in America and Israel, would have a lower rate of protection against the virus than those who offered their arm in the following months. We are not talking, it should be pointed out, of people without defenses. They would simply need another injection to return to a level of effectiveness similar to that acquired after the booster. Covid vaccine: after how much effectiveness drops. From Pfizer to Astrazeneca Summary The US report Israel Laboratory In Italy The cold season The test The US report According to data from the Centers for Disease Control and Prevention, the compound developed by Pfizer is 91% effective in preventing hospitalizations up to four months …

Twelve million people would already need the third dose. This is the number of Italians who got immunized between January and May and who, according to the latest studies published in America and Israel, would have a lower rate of protection against the virus than those who offered the arm in the following months. We are not talking, it should be pointed out, of people without defenses. They would simply need another injection to return to a level of effectiveness similar to that acquired after the booster.

Covid vaccine: after how much effectiveness drops. From Pfizer to Astrazeneca

Summary

According to data from the Centers for Disease Control and Prevention, the compound developed by Pfizer it is 91% effective in preventing hospitalizations for up to four months after the second dose. Then the protection rate drops to 77%. Modern, on the other hand, it maintains similar numbers: after sixteen weeks the vaccine protects 92% from hospitalization, against 93% of those who have just been immunized. On J&J there are no data, because the sample examined did not contain enough people who had received the single-dose, while AstraZeneca it was not taken into consideration, as it was not approved in the US.

Israel it was among the first countries to notice the decline in the effectiveness of antidotes. And he was also the fastest in giving the green light to third dose for all citizens. According to initial data, the booster would raise the neutralization level of antibodies tenfold. Furthermore, according to research published in the New England Journal, the rate of infection detected at least 12 days after the third dose is 11.3 times lower than in those who received only two inoculations. While the severe disease rate is 19.5 times lower. Compared to Delta variant, the Pfizer booster would bring the vaccine efficacy to approximately 95%, a value similar to that reported against the Alpha variant after two doses. “We succeeded – he explains Arnon Shahar, in charge of the Israeli vaccination campaign – to curb the fourth wave of Covid. Almost 60% of those over 60 received the third dose. If we had not done so, we would have been in lockdown for a month and a half. “

In Italy mass vaccinations started in January and the vast majority received Pfizer. This means that twelve million people already have a declining level of protection. Among other things, they are also part of the weaker groups, since our campaign started with health workers, over 80, residents of the Rsa and frail patients. It is no coincidence that this last category is the one for which the government has already triggered the booster. But the risk is that if we do not quickly protect doctors and nurses – the first line against the virus – we could risk having the Covid departments (and not only) in service. “The third dose – as he pointed out Sergio Abrignani, immunologist and member of the CTS, in an interview with our newspaper – it is the only way to beat the virus “.

Also because, in the coming months – those in which the virus will circulate more – they will at least add another 18.4 million Italians, those vaccinated between June and July, which will no longer be effectively protected. “There is no doubt – explains the virologist Massimo Clementi – that there is a need to immediately inject the booster to some categories. Then, based on the progress of the epidemic, a decision will be made whether to extend the third dose to all the others. We are not late. Beyond Israel, which however has a special agreement with Pfizer and is in fact a sort of laboratory-state, we are in line with other nations. We still don’t know if a trio of injections will be enough or if we will have to vaccinate every year. I fear, that for at least three to four years, we will have to offer the arm. “

There are also those who have proposed to perform a test before proceeding to the booster. “As for the third dose for the general population – he concludes Guido Rasi, consultant to the covid emergency commissioner Figliuolo, – there are still some reflections and data to analyze and evaluate. It will be good to try to find a test that tells us if a person is immune or not, so we can decide whether to go on with the third dose or not. “

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