There would be several reasons for developing the research on the nasal Covid-19 vaccine. A solution that has been studied for some time, strongly supported by the cardiologist and professor of the Scripps Research Institute in La Jolla, California, Erico Topol: “I still CAN’T understand why nasal vaccines have not been given top priority, given their remarkable attractiveness to block the transmission of Covid ”he wrote with a tweet citing, as reported by Repubblica, a study recently published in Science.
Covid, the advantages of the nasal spray vaccine: research
The research, carried out by Frances Lund and Troy Randall of the University of Birmingham in Alabama, exposes some advantages of the nasal vaccine against Covid-19. In their work the authors compare the immunity produced by spray vaccines with that obtained by administration by injection.
Nasal vaccination stimulates the synthesis of immunoglobulin A (IgA) like natural infection, while intramuscular vaccines stimulates the synthesis of serum immunoglobulin G (IgG). The first type of antibodies are produced in the mucosal associated lymphoid tissue (MALT) of the digestive and respiratory tract, with a ability to protect the two main channels of communication with the outside of our body from the coronavirus which would be higher than IgG.
According to the study, also direct vaccination of the nasal mucosa it would favor the work of B and T lymphocytes These cells produce long-lasting antibodies and become elements of memory residing in the upper airways.
Covid, the advantages of the nasal spray vaccine: the trials
The authors are amazed that only 7 of the 100 vaccines undergoing clinical trials against Sars-CoV-2 have been created with nasal technology, but in Lund, Sweden, the spray vaccine is about to become a reality.
Currently being tested on mice, the product is being developed by an immunological research start-up, ISR, which will also begin testing on humans in a couple of months.
“It’s easy and it’s really cheap to produce – says CEO Johan Waborg – Just remove a small sheet of plastic. Then the vaccine inhaler is activated, you put it in your mouth, take a deep breath and inhale ”.
However, the search for volunteers for clinical tests has already started at the Irccs San Martino hospital in Genoa, which may soon be able to publish results, with a product available before the end of the year.
The AOS2020 spray, an aqueous solution that contains hypochlorous acid at 0.005%, inhaled into both nostrils 3 to 5 times a day, would allow reduce viral load in the upper respiratory tract in infected people with mild symptoms. Its use could allow prevent more severe symptoms e reduce contagiousness of people and the spread of the virus.
Virgil News | 02-08-2021 11:44